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The Germany playmaker suffered a broken collarbone in Wednesday night's Champions League clash with Napoli, when he clashed with Gokhan Inler while contesting a high ball.
He has been ruled out until after the winter break and club captain Philipp Lahm said: "It was a definite shock and it was immediately noticeable in the way we played.
"We obviously hope that Bastian can get fit again as soon as possible. For now though, we'll carry on without him and are still aiming to take points away from Augsburg on Sunday."
Bayern go into the weekend's programme top of the table by four points after winning eight of their 11 games so far, with Schalke heading the chasing pack and facing Hannover in Sunday's other game.
Saturday's action sees the rest of the leading pack in action with the chance to overhaul the Royal Blues - at least temporarily - and put the pressure on Bayern.
Werder Bremen can count on eight-goal leading scorer Claudio Pizarro against Cologne after the Peru international overcame a muscular injury.
"After yesterday's training Claudio had no more symptoms that would prevent him training," head coach Thomas Schaaf told the club's website.
Pizarro has scored or set up 11 of Bremen's last 12 goals and Schaaf added: "We have more certainty in our game this season, which has benefited Claudio. He is now getting the support he lacked last season, when he could not find a rhythm."
Reigning champions Borussia Dortmund have positive news over the fitness of Sven Bender and Lucas Barrios ahead of their clash with Wolfsburg, for whom Aleksandr Hleb can be expected to play a key role.
The Belarus international arrived recently on loan from Barcelona with a view to a permanent move, but coach Felix Magath has urged patience with the playmaker.
"He is still not fully fit," Magath told www.bundesliga.de.
"But he can still be important in helping us get forward."
Borussia Monchengladbach, who are alongside Dortmund and Bremen on 20 points, travel to Hertha Berlin while Nurnberg host Freiburg, Hoffenheim take on Kaiserslautern and Hamburg travel to Bayer Leverkusen in the evening game.
The weekend's action begins on Friday evening when Mainz host Stuttgart, with the home side's coach Thomas Tuchel insisting "there can be no talk of a collapse" even after a 3-1 defeat to Werder Bremen left them 15th in the table.
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